What exactly is 4-Pro-MET?
4-Pro-MET stands for 4-Propionoxy-N-methyl-N-ethyltryptamine. It's a synthetic tryptamine derivative that acts as a prodrug. Once metabolized, the propionyl ester group gets cleaved, releasing 4-HO-MET (metocin) — that's the pharmacologically active compound.
Think of it like a key that only takes its final shape once it's inside the lock. That's basically what happens during metabolism.
Molecular formula: C₁₆H₂₂N₂O₂. Molar mass: 274.36 g/mol. Researchers value 4-Pro-MET for its predictable pharmacokinetics. Duration sits at roughly 5-8 hours, with onset at 20-60 minutes when taken orally.
As of April 2026, 4-Pro-MET isn't scheduled under Germany's BtMG or NpSG. The propionyloxy substitution doesn't fall under the defined structural features of the NpSG based on current legal interpretation. But laws change. Always check current regulations in your jurisdiction.
From the Research Blog
Frequently Asked Questions
As of April 2026, 4-Pro-MET isn't listed under Germany's BtMG or NpSG. The propionyloxy group doesn't match the NpSG's defined structural features under current interpretation. That said, this isn't legal advice. Check your local laws before ordering.
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